PEX2

Across TCGA cell cohorts, PEX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,468 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PEX2-associated GO terms across cancer lineages are Regulation of RNA polymerase II transcription preinitiation complex assembly, Vacuolar transport, and Regulation of Golgi inheritance. Each is linked with PEX2 in more than 11 cancer types. Because this analysis shows association rather than direction, both PEX2-to-partner and partner-to-PEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA polymerase II transcription preinitiation complex assembly grouped by PEX2-low versus PEX2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX2→partner) and Y-score (partner→PEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.138	+0.645	<.001	<.001	3	12
LUNG_SCLC	Vacuolar transport →	+0.060	+0.960	.001	<.001	2	12
UPPER_AERODIGESTIVE_TRACT	Regulation of Golgi inheritance →	+0.155	+0.855	.001	.005	3	11
OESOPHAGUS	Endosome to lysosome transport →	+0.075	+1.201	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Protein localization to vacuole →	+0.087	+1.135	<.001	<.001	3	11
OESOPHAGUS	Receptor metabolic process →	+0.068	+0.913	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,468 associations by consensus.

Regulation of RNA polymerase II transcription preinitiation complex assembly by PEX2 expression — LARGE_INTESTINE

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