PEX2

Across TCGA cell cohorts, PEX2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PEX2-associated genes across cancer lineages are OR5P3, OR14A2, and OR52B2. Each is linked with PEX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX2-to-partner and partner-to-PEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5P3 grouped by PEX2-low versus PEX2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX2→partner) and Y-score (partner→PEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR5P3 →	+0.034	+3.491	<.001	.008	3	1
PANCREAS	OR14A2 →	+0.012	+4.029	<.001	.007	3	1
PANCREAS	OR52B2 →	+0.021	+3.786	.008	.004	3	1
PANCREAS	OR2S2 →	+0.012	+4.029	<.001	.007	3	1
PANCREAS	TBL1Y →	+0.004	+4.029	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR5P3 by PEX2 expression — PANCREAS

Explore this box plot interactively →