PEX19

Across TCGA cell cohorts, PEX19 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PEX19-associated genes across cancer lineages are OR2T8, TFDP3, and NEXMIF. Each is linked with PEX19 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX19-to-partner and partner-to-PEX19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T8 grouped by PEX19-low versus PEX19-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX19→partner) and Y-score (partner→PEX19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2T8 →	+0.187	+3.693	<.001	.005	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.283	+3.196	<.001	.007	3	1
SKIN	USP17L17 →	+0.006	+4.022	<.001	.006	3	1
SKIN	TP53TG3E →	+0.463	+3.347	<.001	.005	3	1
SKIN	GUCA1A →	+0.413	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR2T8 by PEX19 expression — LARGE_INTESTINE

Explore this box plot interactively →