PEX16

Across TCGA patient cohorts, PEX16 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,152 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PEX16-associated GO terms across cancer lineages are [4Fe-4S] cluster assembly, Sertoli cell development, and Regulation of endoplasmic reticulum tubular network organization. Each is linked with PEX16 in more than 23 cancer types. Because this analysis shows association rather than direction, both PEX16-to-partner and partner-to-PEX16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, [4Fe-4S] cluster assembly grouped by PEX16-low versus PEX16-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX16→partner) and Y-score (partner→PEX16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	[4Fe-4S] cluster assembly →	+0.088	+0.743	<.001	<.001	3	24
ESCA	Sertoli cell development →	-0.089	-0.492	<.001	<.001	3	23
LAML	Regulation of endoplasmic reticulum tubular network organization →	-0.076	-0.676	<.001	<.001	3	21
THYM	Regulation of electron transfer activity →	+0.050	+0.456	<.001	<.001	3	21
DLBC	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	-0.060	-0.820	<.001	<.001	3	21
DLBC	Positive regulation of nitric-oxide synthase biosynthetic process →	-0.066	-0.539	<.001	.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,152 associations by consensus.

[4Fe-4S] cluster assembly by PEX16 expression — DLBC

Explore this box plot interactively →