PEX16

Across TCGA patient cohorts, PEX16 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX16-associated genes across cancer lineages are JNK2, VHL, and ASNS. Each is linked with PEX16 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX16-to-partner and partner-to-PEX16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PEX16-low versus PEX16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX16→partner) and Y-score (partner→PEX16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.295	+3.179	.001	.010	3	1
UCEC	VHL →	-1.441	-2.584	<.001	.011	3	1
UCEC	ASNS →	+0.495	+3.169	.003	.019	2	2
UCEC	Caspase-8 →	-0.233	-2.973	.047	.035	3	1
UCEC	Chk2_pT68 →	-0.183	-3.160	.035	.019	3	1
UCEC	4E-BP1 →	+0.329	+2.584	.009	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK2 by PEX16 expression — UCEC

Explore this box plot interactively →