PEX16

Across TCGA cell cohorts, PEX16 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PEX16-associated genes across cancer lineages are PADI4, OR10W1, and IQCF5. Each is linked with PEX16 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX16-to-partner and partner-to-PEX16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PADI4 grouped by PEX16-low versus PEX16-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX16→partner) and Y-score (partner→PEX16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PADI4 →	+0.079	+3.355	.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.009	+3.562	<.001	.002	3	1
LARGE_INTESTINE	IQCF5 →	+0.021	+3.700	<.001	.009	3	1
OVARY	SPACA1 →	+0.023	+5.807	<.001	.001	3	1
OVARY	GRIFIN →	+0.045	+5.196	<.001	.005	3	1
BLOOD_Leukemia	CRYBB3 →	+0.072	+3.567	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PADI4 by PEX16 expression — LARGE_INTESTINE

Explore this box plot interactively →