PEX14

Across TCGA pan-cancer cohorts, PEX14 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PEX14 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PEX14 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PEX14 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

CESC, COAD, and STAD are the cancer types where PEX14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.121	0.829	<.001	36	view →
COAD	OS	Median	II,III,IV	0.096	0.788	<.001	18	view →
STAD	DFS	Median	III,IV	1.000	0.309	.032	11	view →
LIHC	OS	Median	All	0.129	0.707	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PEX14–CESC (OS)

Open the CESC breakdown →