PEX14

Across TCGA patient cohorts, PEX14 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX14-associated genes across cancer lineages are S6_pS235_S236, PKC-a_pS657, and eIF4E. Each is linked with PEX14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX14-to-partner and partner-to-PEX14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS235_S236 grouped by PEX14-low versus PEX14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX14→partner) and Y-score (partner→PEX14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS235_S236 →	+0.463	+3.000	.041	.036	3	1
UCEC	PKC-a_pS657 →	-0.531	-3.308	.007	.010	2	1
UCEC	eIF4E →	+0.243	+3.321	.028	.010	1	1
UCEC	GSK3-a-b →	-0.161	-3.321	.023	.010	1	1
UCEC	MEK1 →	+0.571	+3.321	.002	.010	1	1
UCEC	PKC-a →	-0.544	-3.321	.010	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

S6_pS235_S236 by PEX14 expression — UCEC

Explore this box plot interactively →