PEX14

Across TCGA cell cohorts, PEX14 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEX14-associated genes across cancer lineages are OR10T2, OR10K2, and PABPC1L2A. Each is linked with PEX14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX14-to-partner and partner-to-PEX14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by PEX14-low versus PEX14-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX14→partner) and Y-score (partner→PEX14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	2
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
CNS	OR4F6 →	+0.019	+5.321	<.001	.005	3	1
CNS	OR52E6 →	+0.035	+5.754	<.001	.002	3	1
CNS	CT47A7 →	+0.020	+6.357	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

OR10T2 by PEX14 expression — BREAST

Explore this box plot interactively →