PEX14

Across TCGA cell cohorts, PEX14 mutation is significantly associated with the mutation status of many other genes, with 2,916 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PEX14-associated genes across cancer lineages are CEP295, FBXL16, and RPL22. Each is linked with PEX14 in more than 2 cancer types. Because this analysis shows association rather than direction, both PEX14-to-partner and partner-to-PEX14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP295 grouped by PEX14-low versus PEX14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX14→partner) and Y-score (partner→PEX14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEP295 →	+2.284	+3.925	.005	.005	1	3
BREAST	FBXL16 →	+5.297	+5.297	.004	.004	1	3
BLOOD_Leukemia	RPL22 →	+2.591	+3.263	.004	.004	1	3
BLOOD_Leukemia	PPL →	+2.243	+2.959	.008	.008	1	3
CNS	PTPRB →	+4.044	+5.000	.008	.008	1	3
BLOOD_Leukemia	ZSCAN10 →	+2.787	+3.962	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,916 associations by consensus.

CEP295 by PEX14 expression — LARGE_INTESTINE

Explore this box plot interactively →