PEX12

Across TCGA pan-cancer cohorts, PEX12 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PEX12 data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PEX12 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PEX12 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUSC, and ESCA are the cancer types where PEX12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.947	0.629	.033	10	view →
LUSC	DFS	Median	II,III,IV	0.124	0.709	<.001	9	view →
ESCA	OS	Median	II,III,IV	0.321	0.685	.035	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PEX12–UCEC (DFS)

Open the UCEC breakdown →