PEX12

Across TCGA cell cohorts, PEX12 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PEX12-associated genes across cancer lineages are CYP1A2, ZIC3, and DCLK3. Each is linked with PEX12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX12-to-partner and partner-to-PEX12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP1A2 grouped by PEX12-low versus PEX12-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX12→partner) and Y-score (partner→PEX12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYP1A2 →	+0.030	+4.125	.001	.008	3	1
BLOOD_Leukemia	ZIC3 →	+0.015	+4.060	<.001	.003	3	1
BLOOD_Leukemia	DCLK3 →	+0.161	+3.769	.003	.008	3	1
BLOOD_Leukemia	GPR101 →	+0.133	+3.551	<.001	.009	3	1
BLOOD_Leukemia	INSM2 →	+0.191	+3.769	<.001	.008	3	1
BLOOD_Leukemia	WFDC12 →	+0.198	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

CYP1A2 by PEX12 expression — BLOOD_Leukemia

Explore this box plot interactively →