PEX11B

Across TCGA patient cohorts, PEX11B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX11B-associated genes across cancer lineages are JNK_pT183_Y185, Myosin-IIa, and p70-S6K_pT389. Each is linked with PEX11B in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX11B-to-partner and partner-to-PEX11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by PEX11B-low versus PEX11B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX11B→partner) and Y-score (partner→PEX11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.258	-3.446	.002	.005	3	1
UCEC	Myosin-IIa →	+0.257	+3.329	.008	.005	3	1
UCEC	p70-S6K_pT389 →	-0.261	-2.321	.006	.035	3	1
UCEC	Paxillin →	+0.336	+2.817	.009	.036	3	1
UCEC	STAT3_pY705 →	-0.468	-2.321	<.001	.035	3	1
UCEC	ASNS →	+0.381	+2.321	.035	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

JNK_pT183_Y185 by PEX11B expression — UCEC

Explore this box plot interactively →