PEX10

Across TCGA patient cohorts, PEX10 mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX10-associated genes across cancer lineages are MIR8071-2, OTULIN, and FCRL3. Each is linked with PEX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX10-to-partner and partner-to-PEX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8071-2 grouped by PEX10-low versus PEX10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX10→partner) and Y-score (partner→PEX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR8071-2 →	+1.721	+2.864	<.001	<.001	3	1
UCEC	OTULIN →	+0.472	+3.595	.003	.001	3	1
UCEC	FCRL3 →	+0.703	+3.595	<.001	.001	3	1
UCEC	SNRNP25 →	+0.566	+3.660	.002	.001	3	1
UCEC	KBTBD8 →	+0.444	+3.243	.001	.008	3	1
UCEC	EOMES →	+0.752	+3.346	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

MIR8071-2 by PEX10 expression — UCEC

Explore this box plot interactively →