PEX1

Across TCGA pan-cancer cohorts, PEX1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PEX1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PEX1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PEX1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where PEX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.489	.008	24	view →
PDAC	DFS	Tertile	All	0.591	0.285	<.001	12	view →
CCRCC	OS	Tertile	All	1.000	0.897	.027	9	view →
LUAD	DFS	Tertile	All	0.453	0.767	.008	8	view →
GBM	OS	Median	All	0.749	0.876	.016	4	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.752	.009	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PEX1–UCEC (DFS)

Open the UCEC breakdown →