PEX1

Across TCGA patient cohorts, PEX1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX1-associated genes across cancer lineages are INPP4B, EGFR_pY1068, and A-Raf_pS299. Each is linked with PEX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PEX1-to-partner and partner-to-PEX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by PEX1-low versus PEX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX1→partner) and Y-score (partner→PEX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.281	-2.999	.008	<.001	3	4
UCEC	EGFR_pY1068 →	-0.278	-1.938	<.001	.001	3	2
UCEC	A-Raf_pS299 →	-0.144	-2.700	<.001	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.132	-1.584	.017	.034	3	2
UCEC	JNK2 →	+0.281	+2.643	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.430	+1.505	.013	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

INPP4B by PEX1 expression — UCEC

Explore this box plot interactively →