PEX1

Across TCGA cell cohorts, PEX1 mutation is significantly associated with the RNA expression of many other genes, with 723 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEX1-associated genes across cancer lineages are OR2T8, CLEC10A, and NAT8B. Each is linked with PEX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX1-to-partner and partner-to-PEX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T8 grouped by PEX1-low versus PEX1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX1→partner) and Y-score (partner→PEX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2T8 →	+0.103	+2.219	.004	.001	3	2
OESOPHAGUS	CLEC10A →	+0.022	+4.017	<.001	.007	3	1
OESOPHAGUS	NAT8B →	+0.033	+4.017	.001	.007	3	1
BLOOD_Leukemia	IGFL3 →	+0.043	+5.121	<.001	<.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.537	+2.829	<.001	<.001	3	1
LARGE_INTESTINE	DEPDC5 →	+0.460	+3.321	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 723 associations by consensus.

OR2T8 by PEX1 expression — LARGE_INTESTINE

Explore this box plot interactively →