PET117

Across TCGA patient cohorts, PET117 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PET117-associated genes across cancer lineages are OR6K3, RN7SKP232, and RPL31P54. Each is linked with PET117 in more than 1 cancer types. Because this analysis shows association rather than direction, both PET117-to-partner and partner-to-PET117 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6K3 grouped by PET117-low versus PET117-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PET117→partner) and Y-score (partner→PET117) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR6K3 →	+0.306	+4.982	<.001	.009	3	1
UCEC	RN7SKP232 →	+0.372	+5.133	<.001	.008	3	1
UCEC	RPL31P54 →	+0.405	+5.420	<.001	.005	3	1
UCEC	MIR548AC →	+1.065	+5.242	<.001	.007	3	1
UCEC	ATP6V1G1P5 →	+0.320	+5.621	<.001	.004	3	1
UCEC	RN7SL828P →	+0.357	+5.081	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR6K3 by PET117 expression — UCEC

Explore this box plot interactively →