PES1

Across TCGA pan-cancer cohorts, PES1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PES1 data layer compared with 29 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PES1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PES1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where PES1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.378	0.649	<.001	71	view →
CCRCC	DFS	Median	III,IV	0.365	0.780	<.001	64	view →
LUAD	DFS	Median	III,IV	0.805	0.247	.001	34	view →
GBM	OS	Median	All	0.492	0.282	.003	8	view →
LSCC	DFS	Median	II,III,IV	0.851	0.541	.011	8	view →
HNSC	OS	Median	All	0.816	0.891	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PES1–PDAC (OS)

Open the PDAC breakdown →