PERP

Across TCGA cell cohorts, PERP RNA expression is significantly associated with the go_rna of many other GO terms, with 5,465 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PERP-associated GO terms across cancer lineages are Mammary gland morphogenesis, Cell-substrate junction organization, and Mammary gland development. Each is linked with PERP in more than 11 cancer types. Because this analysis shows association rather than direction, both PERP-to-partner and partner-to-PERP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mammary gland morphogenesis grouped by PERP-low versus PERP-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PERP→partner) and Y-score (partner→PERP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Mammary gland morphogenesis →	+0.280	+2.229	<.001	<.001	3	12
URINARY_TRACT	Cell-substrate junction organization →	+0.227	+2.316	<.001	<.001	3	12
URINARY_TRACT	Mammary gland development →	+0.180	+2.704	<.001	<.001	3	12
BONE	Small GTPase-mediated signal transduction →	+0.065	+2.946	<.001	.001	3	12
SKIN	Bundle of His cell to Purkinje myocyte communication →	+0.655	+1.789	.008	.007	3	11
STOMACH	Positive regulation of proteolysis →	+0.153	+2.793	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,465 associations by consensus.

Mammary gland morphogenesis by PERP expression — LUNG_SCLC

Explore this box plot interactively →