Across TCGA patient cohorts, PERM1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PERM1-associated genes across cancer lineages are FOXO3a_pS318_S321, MEK1, and Myosin-IIa. Each is linked with PERM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PERM1-to-partner and partner-to-PERM1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PERM1→partner) and Y-score (partner→PERM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.142	-3.000	.048	.037	3	1
UCEC	MEK1 →	+0.420	+3.000	.047	.037	3	1
UCEC	Myosin-IIa →	-0.273	-2.992	.010	.036	3	1
UCEC	AMPK_alpha →	+0.299	+3.000	.006	.037	2	1
UCEC	p62 Lck ligand →	+0.642	+3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

PERM1 survival (RNA) · tumor vs normal (RNA) · all PERM1 data types