PER2

Across TCGA cell cohorts, PER2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,914 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PER2-associated GO terms across cancer lineages are Regulation of glutamate uptake involved in transmission of nerve impulse, Regulation of L-glutamate import across plasma membrane, and Lactate metabolic process. Each is linked with PER2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PER2-to-partner and partner-to-PER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of glutamate uptake involved in transmission of nerve impulse grouped by PER2-low versus PER2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PER2→partner) and Y-score (partner→PER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of glutamate uptake involved in transmission of nerve impulse →	-0.213	-1.110	<.001	<.001	3	17
LIVER	Regulation of L-glutamate import across plasma membrane →	-0.283	-1.160	<.001	<.001	3	15
BREAST	Lactate metabolic process →	-0.209	-0.942	<.001	<.001	3	14
BREAST	Negative regulation of circadian rhythm →	+0.159	+0.984	<.001	<.001	3	13
BLOOD_Leukemia	Positive regulation of cytoplasmic mRNA processing body assembly →	+0.094	+0.483	<.001	<.001	3	12
BONE	Late viral transcription →	+0.115	+0.691	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,914 associations by consensus.

Regulation of glutamate uptake involved in transmission of nerve impulse by PER2 expression — LIVER

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