PER2

Across TCGA cell cohorts, PER2 mutation is significantly associated with the RNA expression of many other genes, with 491 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PER2-associated genes across cancer lineages are GID4, TRMT10A, and FGF23. Each is linked with PER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PER2-to-partner and partner-to-PER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GID4 grouped by PER2-low versus PER2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PER2→partner) and Y-score (partner→PER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GID4 →	+0.631	+3.237	.001	.003	3	2
LARGE_INTESTINE	TRMT10A →	+0.705	+3.212	.001	.006	3	2
LUNG_NSCLC_LUAD	FGF23 →	+0.069	+3.108	.002	.001	3	2
SKIN	SPINK9 →	+0.043	+4.415	<.001	.007	3	2
OESOPHAGUS	TSPY10 →	+0.038	+4.017	.001	.007	3	1
LARGE_INTESTINE	HMGXB4 →	+0.572	+3.212	.005	.006	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 491 associations by consensus.

GID4 by PER2 expression — LARGE_INTESTINE

Explore this box plot interactively →