PER1

Across TCGA pan-cancer cohorts, PER1 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated PER1 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PER1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PER1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UVM, BLCA, and LIHC are the cancer types where PER1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.213	0.718	.002	27	view →
BLCA	OS	Median	All	0.063	0.688	<.001	24	view →
LIHC	DFS	Median	III,IV	0.076	0.360	.001	24	view →
UCEC	DFS	Median	II,III,IV	0.937	0.428	.006	22	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
READ	OS	Median	II,III,IV	0.187	0.644	.023	12	view →
SARC	DFS	Median	All	0.238	0.613	.028	6	view →
LGG	OS	Median	All	0.163	0.889	<.001	6	view →
ESCA	DFS	Median	III,IV	0.162	0.447	.034	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	III,IV	0.320	0.729	.024	3	view →
LUSC	DFS	Median	All	1.000	0.369	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

PER1–UVM (OS)

Open the UVM breakdown →