PER1

Across TCGA pan-cancer cohorts, PER1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PER1 data layer compared with 26 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PER1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PER1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where PER1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.223	0.644	<.001	27	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
LSCC	DFS	Tertile	II,III,IV	0.867	1.000	.035	2	view →
HNSC	DFS	Tertile	III,IV	0.949	0.333	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PER1–PDAC (DFS)

Open the PDAC breakdown →