PER1

Across TCGA patient cohorts, PER1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PER1-associated genes across cancer lineages are Chk1, PDCD4, and Rad50. Each is linked with PER1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PER1-to-partner and partner-to-PER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by PER1-low versus PER1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PER1→partner) and Y-score (partner→PER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.265	+2.619	.002	.005	3	3
UCEC	PDCD4 →	-0.377	-2.222	.009	.009	3	3
COAD	Rad50 →	-0.298	-2.450	.004	.020	3	2
UCEC	ATM →	-0.630	-4.308	<.001	<.001	3	2
COAD	c-Kit →	-0.857	-2.450	<.001	.020	3	2
SKCM	ASNS →	+0.528	+3.321	.008	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Chk1 by PER1 expression — SKCM

Explore this box plot interactively →