PER1

Across TCGA cell cohorts, PER1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,074 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PER1-associated GO terms across cancer lineages are Regulation of nuclear receptor-mediated glucocorticoid signaling pathway, Circadian regulation of gene expression, and Negative regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with PER1 in more than 18 cancer types. Because this analysis shows association rather than direction, both PER1-to-partner and partner-to-PER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nuclear receptor-mediated glucocorticoid signaling pathway grouped by PER1-low versus PER1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PER1→partner) and Y-score (partner→PER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of nuclear receptor-mediated glucocorticoid signaling pathway →	+0.124	+1.349	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Circadian regulation of gene expression →	+0.095	+1.831	.009	.005	3	12
STOMACH	Negative regulation of intracellular steroid hormone receptor signaling pathway →	+0.112	+1.164	<.001	.001	2	12
CNS	Regulation of autophagosome maturation →	+0.079	+0.596	<.001	.009	3	11
LARGE_INTESTINE	Regulation of intracellular steroid hormone receptor signaling pathway →	+0.088	+1.110	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Circadian rhythm →	+0.066	+1.404	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,074 associations by consensus.

Regulation of nuclear receptor-mediated glucocorticoid signaling pathway by PER1 expression — LUNG_NSCLC_LUSC

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