PER1

Across TCGA cell cohorts, PER1 mutation is significantly associated with the RNA expression of many other genes, with 704 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PER1-associated genes across cancer lineages are TAS2R39, PRAM1, and TKTL2. Each is linked with PER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PER1-to-partner and partner-to-PER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R39 grouped by PER1-low versus PER1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PER1→partner) and Y-score (partner→PER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAS2R39 →	+0.041	+3.339	.003	.006	3	2
LARGE_INTESTINE	PRAM1 →	+0.246	+3.588	.005	<.001	3	2
LARGE_INTESTINE	TKTL2 →	+0.028	+2.509	.005	.005	3	2
BLOOD_Lymphoma	BANF2 →	+0.035	+4.643	.003	.005	3	1
BLOOD_Lymphoma	CSN1S1 →	+0.125	+4.927	<.001	.001	3	1
BLOOD_Lymphoma	STATH →	+0.442	+4.350	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 704 associations by consensus.

TAS2R39 by PER1 expression — BLOOD_Leukemia

Explore this box plot interactively →