PEPD

Across TCGA patient cohorts, PEPD mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEPD-associated genes across cancer lineages are eIF4E, EGFR_pY1068, and eIF4G. Each is linked with PEPD in more than 1 cancer types. Because this analysis shows association rather than direction, both PEPD-to-partner and partner-to-PEPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PEPD-low versus PEPD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEPD→partner) and Y-score (partner→PEPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.184	+1.678	.022	.023	3	2
UCEC	EGFR_pY1068 →	-0.232	-1.678	.016	.023	3	1
UCEC	eIF4G →	+0.342	+2.584	.004	.001	3	1
UCEC	A-Raf_pS299 →	-0.169	-2.584	<.001	.010	3	1
UCEC	ERK2 →	+0.182	+2.000	.013	.029	3	1
UCEC	FOXO3a_pS318_S321 →	-0.118	-2.087	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eIF4E by PEPD expression — UCEC

Explore this box plot interactively →