PEPD

Across TCGA cell cohorts, PEPD mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEPD-associated genes across cancer lineages are 50869, 776928, and Ispinesib Mesylate. Each is linked with PEPD in more than 1 cancer types. Because this analysis shows association rather than direction, both PEPD-to-partner and partner-to-PEPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 50869 grouped by PEPD-low versus PEPD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEPD→partner) and Y-score (partner→PEPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	50869 →	+0.431	+2.649	.041	.046	3	1
LARGE_INTESTINE	776928 →	+0.696	+2.710	.027	.027	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.668	+2.652	.041	.045	3	1
LARGE_INTESTINE	GSK626616AC →	+0.415	+2.777	.008	.038	1	2
LARGE_INTESTINE	Gallibiscoquinazole →	+0.333	+2.649	.043	.046	2	1
LARGE_INTESTINE	L-Oxonoreleagnine →	+0.412	+2.777	.004	.038	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

50869 by PEPD expression — LARGE_INTESTINE

Explore this box plot interactively →