PEMT

Across TCGA cell cohorts, PEMT mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEMT-associated genes across cancer lineages are ZNF831, S100G, and GSC2. Each is linked with PEMT in more than 1 cancer types. Because this analysis shows association rather than direction, both PEMT-to-partner and partner-to-PEMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by PEMT-low versus PEMT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEMT→partner) and Y-score (partner→PEMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.010	+4.273	.004	.006	3	1
LARGE_INTESTINE	S100G →	+2.038	+4.273	<.001	.006	3	1
LARGE_INTESTINE	GSC2 →	+0.168	+4.273	<.001	.006	3	1
LARGE_INTESTINE	ENTHD1 →	+0.032	+4.139	.004	.007	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ZNF831 by PEMT expression — LARGE_INTESTINE

Explore this box plot interactively →