PELP1

Across TCGA patient cohorts, PELP1 mutation is significantly associated with the RNA expression of many other genes, with 2,031 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PELP1-associated genes across cancer lineages are GBP2, RASSF1-AS1, and IGHV2-70. Each is linked with PELP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PELP1-to-partner and partner-to-PELP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GBP2 grouped by PELP1-low versus PELP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PELP1→partner) and Y-score (partner→PELP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GBP2 →	+0.795	+3.362	.001	.004	3	3
COAD	RASSF1-AS1 →	+0.390	+2.820	<.001	.001	3	3
UCEC	IGHV2-70 →	+1.542	+3.708	.001	<.001	3	3
UCEC	IGHV1-69 →	+1.930	+2.716	<.001	.003	3	3
LGG	RNU6-681P →	+0.369	+5.039	<.001	.009	3	2
LGG	CT47B1 →	+0.036	+5.327	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,031 associations by consensus.

GBP2 by PELP1 expression — COAD

Explore this box plot interactively →