PELI3

Across TCGA patient cohorts, PELI3 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PELI3-associated genes across cancer lineages are Astrocytes, CD8+ Tem, and NK cells. Each is linked with PELI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PELI3-to-partner and partner-to-PELI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Astrocytes grouped by PELI3-low versus PELI3-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PELI3→partner) and Y-score (partner→PELI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	Astrocytes →	+0.114	+3.111	.004	.036	3	1
STAD	CD8+ Tem →	+0.011	+3.567	<.001	.020	3	1
STAD	NK cells →	+0.006	+4.597	<.001	.005	3	1
UCEC	CD8+ naive T-cells →	+0.027	+2.202	.011	.033	3	1
UCEC	Endothelial cells →	-0.033	-3.161	.026	.019	3	1
UCEC	pDC →	+0.067	+2.617	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Astrocytes by PELI3 expression — LGG

Explore this box plot interactively →