PELI3

Across TCGA cell cohorts, PELI3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PELI3-associated genes across cancer lineages are CD40LG, SIRPD, and C1orf146. Each is linked with PELI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PELI3-to-partner and partner-to-PELI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD40LG grouped by PELI3-low versus PELI3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PELI3→partner) and Y-score (partner→PELI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CD40LG →	+0.011	+4.285	.004	.003	3	1
BLOOD_Myeloma	SIRPD →	+0.011	+3.906	<.001	.009	3	1
BLOOD_Myeloma	C1orf146 →	+0.107	+3.906	<.001	.009	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.325	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CXorf51B →	+1.088	+5.228	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CD40LG by PELI3 expression — BLOOD_Myeloma

Explore this box plot interactively →