Across TCGA cell cohorts, PEG3 mutation is significantly associated with the RNA expression of many other genes, with 755 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEG3-associated genes across cancer lineages are DEPDC5, RPF1, and AMIGO3. Each is linked with PEG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PEG3-to-partner and partner-to-PEG3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEG3→partner) and Y-score (partner→PEG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEPDC5 →	+0.408	+1.906	.007	.001	3	3
LARGE_INTESTINE	RPF1 →	+0.568	+1.866	<.001	<.001	3	3
LARGE_INTESTINE	AMIGO3 →	+0.457	+1.237	<.001	.006	3	3
LUNG_NSCLC_LUAD	FBXW10 →	+0.486	+2.358	.006	.001	3	3
OESOPHAGUS	H2BW2 →	+0.210	+3.544	.005	.001	3	2
OESOPHAGUS	GPBAR1 →	+0.082	+3.196	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 755 associations by consensus.

Exploration

PEG3 survival (RNA) · tumor vs normal (RNA) · all PEG3 data types