PEG10

Across TCGA patient cohorts, PEG10 mutation is significantly associated with the RNA expression of many other genes, with 4,848 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEG10-associated genes across cancer lineages are MRPS36, MIR508, and PLA2G3. Each is linked with PEG10 in more than 3 cancer types. Because this analysis shows association rather than direction, both PEG10-to-partner and partner-to-PEG10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS36 grouped by PEG10-low versus PEG10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEG10→partner) and Y-score (partner→PEG10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS36 →	+0.326	+1.906	<.001	.001	3	4
STAD	MIR508 →	+0.524	+4.561	<.001	.004	3	3
UCEC	PLA2G3 →	+0.593	+2.321	<.001	<.001	3	3
UCEC	PHF5A →	+0.457	+2.841	<.001	<.001	3	3
UCEC	GMDS →	+0.437	+1.355	.001	.003	3	3
UCEC	NEK4 →	+0.479	+1.645	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,848 associations by consensus.

MRPS36 by PEG10 expression — UCEC

Explore this box plot interactively →