PEG10

Across TCGA patient cohorts, PEG10 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEG10-associated genes across cancer lineages are Shc_pY317, ATM, and Di-Ras3. Each is linked with PEG10 in more than 2 cancer types. Because this analysis shows association rather than direction, both PEG10-to-partner and partner-to-PEG10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by PEG10-low versus PEG10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEG10→partner) and Y-score (partner→PEG10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.115	-1.485	.009	.003	3	3
UCEC	ATM →	-0.317	-1.115	.016	.026	3	3
UCEC	Di-Ras3 →	-0.132	-1.986	.002	.008	3	3
UCEC	eIF4E →	+0.179	+2.428	.003	.001	3	2
UCEC	p27_pT157 →	-0.045	-1.234	.008	.038	3	2
UCEC	Caspase-7-cleavedD198 →	+0.486	+1.460	.004	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Shc_pY317 by PEG10 expression — UCEC

Explore this box plot interactively →