PEG10

Across TCGA cell cohorts, PEG10 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PEG10-associated genes across cancer lineages are GJA10, GADL1, and OCSTAMP. Each is linked with PEG10 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEG10-to-partner and partner-to-PEG10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJA10 grouped by PEG10-low versus PEG10-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEG10→partner) and Y-score (partner→PEG10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GJA10 →	+0.045	+3.628	<.001	.002	3	1
LUNG_NSCLC_LUAD	GADL1 →	+0.063	+3.971	<.001	.004	3	1
LUNG_NSCLC_LUAD	OCSTAMP →	+0.011	+3.343	<.001	.005	3	1
LUNG_NSCLC_LUAD	ASZ1 →	+0.462	+3.157	<.001	.008	3	1
LUNG_NSCLC_LUAD	XAGE3 →	+0.104	+3.215	<.001	.007	3	1
LUNG_NSCLC_LUAD	TRIM49C →	+0.019	+3.343	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GJA10 by PEG10 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →