PEF1

Across TCGA pan-cancer cohorts, PEF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PEF1 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PEF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PEF1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and OV show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where PEF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.869	0.266	.006	8	view →
CCRCC	OS	Median	IV	0.451	1.000	.016	5	view →
LSCC	DFS	Median	III,IV	0.511	0.811	.041	5	view →
OV	DFS	Quartile	All	0.884	0.642	.035	4	view →
HNSC	OS	Quartile	All	0.941	0.773	.014	3	view →
LUAD	DFS	Quartile	All	0.817	0.389	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PEF1–PDAC (DFS)

Open the PDAC breakdown →