PEF1

Across TCGA patient cohorts, PEF1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEF1-associated genes across cancer lineages are Shc_pY317, A-Raf_pS299, and Gab2. Each is linked with PEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEF1-to-partner and partner-to-PEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by PEF1-low versus PEF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEF1→partner) and Y-score (partner→PEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.180	-2.321	.018	.035	3	2
UCEC	A-Raf_pS299 →	-0.148	-3.000	.013	.036	3	1
UCEC	Gab2 →	+0.500	+2.321	.005	.035	3	1
UCEC	GATA6 →	-0.184	-3.000	.022	.035	3	1
UCEC	PCNA →	+0.262	+2.321	.015	.035	3	1
UCEC	PRAS40_pT246 →	+0.198	+3.000	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Shc_pY317 by PEF1 expression — UCEC

Explore this box plot interactively →