PEDS1

Across TCGA pan-cancer cohorts, PEDS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PEDS1 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PEDS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PEDS1 expression acts as an unfavorable survival marker.

HNSC, PDAC, and LUAD are the cancer types where PEDS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.290	0.947	.008	24	view →
PDAC	DFS	Median	All	0.237	0.481	.001	13	view →
LUAD	DFS	Tertile	All	0.219	1.000	.003	12	view →
LSCC	DFS	Quartile	All	0.262	0.916	.004	11	view →
UCEC	DFS	Tertile	All	0.786	1.000	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PEDS1–HNSC (DFS)

Open the HNSC breakdown →