PEDS1

Across TCGA patient cohorts, PEDS1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEDS1-associated genes across cancer lineages are eIF4E, PDK1_pS241, and Myosin-IIa. Each is linked with PEDS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEDS1-to-partner and partner-to-PEDS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PEDS1-low versus PEDS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEDS1→partner) and Y-score (partner→PEDS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.274	+3.000	.024	.037	3	2
UCEC	PDK1_pS241 →	+0.196	+2.833	.047	.034	3	1
UCEC	Myosin-IIa →	+0.288	+2.814	.010	.036	1	1
UCEC	Shc_pY317 →	-0.177	-3.000	.043	.037	1	1
UCEC	Axl →	+0.352	+2.843	.005	.035	1	1
UCEC	Di-Ras3 →	-0.213	-3.000	.013	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

eIF4E by PEDS1 expression — UCEC

Explore this box plot interactively →