PEDS1

Across TCGA cell cohorts, PEDS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,890 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PEDS1-associated GO terms across cancer lineages are Protein targeting to membrane, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, and Negative regulation of response to endoplasmic reticulum stress. Each is linked with PEDS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both PEDS1-to-partner and partner-to-PEDS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to membrane grouped by PEDS1-low versus PEDS1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PEDS1→partner) and Y-score (partner→PEDS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein targeting to membrane →	+0.071	+0.823	.002	.001	3	12
KIDNEY	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.179	+1.244	<.001	<.001	3	11
URINARY_TRACT	Negative regulation of response to endoplasmic reticulum stress →	+0.140	+0.844	<.001	<.001	3	11
KIDNEY	Protein localization to endoplasmic reticulum →	+0.128	+1.187	.007	.003	3	11
PANCREAS	Response to unfolded protein →	+0.100	+1.120	<.001	<.001	3	11
STOMACH	IRE1-mediated unfolded protein response →	+0.191	+0.996	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,890 associations by consensus.

Protein targeting to membrane by PEDS1 expression — BONE

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