Across TCGA pan-cancer cohorts, PEBP1P1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PEBP1P1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PEBP1P1 RNA is repressed in tumor relative to normal tissue. In most cancer types PEBP1P1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.
KIRC, THCA, and KICH are the cancer types where PEBP1P1 tumor–normal differential expression is most reproducible.