Across TCGA pan-cancer cohorts, PEAR1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PEAR1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PEAR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PEAR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where PEAR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.736	0.975	.001	34	view →
PDAC	DFS	Quartile	All	0.235	0.776	.047	3	view →
CCRCC	OS	Tertile	II,III,IV	0.288	0.978	.024	2	view →
HNSC	DFS	Tertile	IV	0.987	0.698	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PEAR1 tumor-vs-normal RNA expression · all PEAR1 data types