Across TCGA patient cohorts, PEAR1 mutation is significantly associated with the RNA expression of many other genes, with 3,085 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEAR1-associated genes across cancer lineages are LIN52, PROSER1, and KLK10. Each is linked with PEAR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PEAR1-to-partner and partner-to-PEAR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEAR1→partner) and Y-score (partner→PEAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LIN52 →	+0.330	+1.803	.009	.006	3	3
UCEC	PROSER1 →	+0.513	+2.284	<.001	<.001	3	3
UCEC	KLK10 →	-1.370	-1.927	<.001	.001	3	3
UCEC	UBR7 →	+0.468	+2.606	<.001	<.001	3	3
UCEC	ZNF317 →	+0.386	+1.981	.001	<.001	3	3
UCEC	TGFBRAP1 →	+0.431	+1.872	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,085 associations by consensus.

Exploration

PEAR1 survival (RNA) · tumor vs normal (RNA) · all PEAR1 data types