Across TCGA patient cohorts, PEAR1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEAR1-associated genes across cancer lineages are PDCD4, Rad50, and PDK1. Each is linked with PEAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEAR1-to-partner and partner-to-PEAR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEAR1→partner) and Y-score (partner→PEAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.513	-1.502	.002	.030	3	2
UCEC	Rad50 →	-0.200	-1.847	.024	.008	3	2
LUAD	PDK1 →	-0.157	-3.000	.009	.035	3	1
UCEC	14-3-3_beta →	-0.116	-2.673	.001	.005	3	1
UCEC	ERK2 →	+0.171	+2.000	.015	.029	3	1
UCEC	FOXO3a_pS318_S321 →	-0.095	-2.312	.037	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

PEAR1 survival (RNA) · tumor vs normal (RNA) · all PEAR1 data types