Across TCGA cell cohorts, PEAK3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PEAK3-associated genes across cancer lineages are USP17L17, GPHB5, and TPPP2. Each is linked with PEAK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEAK3-to-partner and partner-to-PEAK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEAK3→partner) and Y-score (partner→PEAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	USP17L17 →	+0.010	+5.022	<.001	.002	3	2
SOFT_TISSUE	GPHB5 →	+0.097	+4.977	<.001	.002	3	1
SOFT_TISSUE	TPPP2 →	+0.134	+5.515	<.001	<.001	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
SKIN	AKAIN1 →	+0.095	+4.930	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

PEAK3 survival (RNA) · tumor vs normal (RNA) · all PEAK3 data types