PEAK1

Across TCGA patient cohorts, PEAK1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEAK1-associated genes across cancer lineages are ASNS, Annexin-1, and c-Kit. Each is linked with PEAK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PEAK1-to-partner and partner-to-PEAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PEAK1-low versus PEAK1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEAK1→partner) and Y-score (partner→PEAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ASNS →	+0.503	+3.009	.030	.019	3	3
UCEC	Annexin-1 →	+0.678	+2.050	<.001	<.001	3	3
UCEC	c-Kit →	-0.150	-1.378	.031	.008	3	3
LUSC	ACC_pS79 →	+0.366	+2.821	.043	.035	3	2
LUSC	TIGAR →	+0.148	+3.045	.042	.018	2	3
COAD	Caspase-7-cleavedD198 →	+1.916	+2.824	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ASNS by PEAK1 expression — LUSC

Explore this box plot interactively →