PEAK1

Across TCGA cell cohorts, PEAK1 mutation is significantly associated with the RNA expression of many other genes, with 588 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEAK1-associated genes across cancer lineages are PRR23A, PLTP, and DTWD1. Each is linked with PEAK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEAK1-to-partner and partner-to-PEAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23A grouped by PEAK1-low versus PEAK1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEAK1→partner) and Y-score (partner→PEAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRR23A →	+0.030	+4.000	<.001	<.001	3	2
LARGE_INTESTINE	PLTP →	-1.674	-2.179	.005	.004	3	2
LARGE_INTESTINE	DTWD1 →	+0.625	+2.949	<.001	<.001	3	2
LARGE_INTESTINE	MRPL35 →	+0.533	+3.389	<.001	.001	3	2
LARGE_INTESTINE	METTL5 →	+0.306	+2.386	.001	.007	3	2
LARGE_INTESTINE	TOM1L1 →	+0.590	+3.321	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 588 associations by consensus.

PRR23A by PEAK1 expression — URINARY_TRACT

Explore this box plot interactively →